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[DOI] [PubMed] [Google Scholar] 75.Ilic S., Drmic D., Zarkovic K., Kolenc D., Coric M., Brcic L., Klicek R., Radic B., Sever M., Djuzel V., et al

Active skin infection, unexplained rash, sudden swelling, severe pain, unresolved digestive symptoms, pregnancy, breastfeeding, cancer history, immune concerns, medication conflicts, or unexplained medical symptoms may require closer review

M., Szczepanski, L

Some patients may experience a transient increase in acne or rosacea-like skin reactions, thought to be related to the effects of vitamin B12 on skin bacteria, though this is uncommon and typically mild

Gut-brain axis effects: Research suggests BPC-157 influences the gut-brain axis, potentially explaining reported cognitive and mood benefits alongside physical healing